Amaryl MSR 1/500MG Tab (3 Strips = 30 Tablets)

Comprehensive Blood Sugar Control in One Tablet

Amaryl M S.R. Tablets 1mg/500mg combine two established antidiabetic agents—Glimepiride and Metformin HCl—into a single sustained-release formulation designed for effective management of Type 2 Diabetes Mellitus. This combination therapy is specifically indicated for patients whose blood sugar levels are not adequately controlled with either medication alone.

By targeting multiple pathways involved in glucose regulation, Amaryl M S.R. delivers enhanced glycemic control while supporting long-term diabetes management.

Dual Mechanism for Superior Glycemic Control

The effectiveness of Amaryl M S.R. lies in its complementary dual-action mechanism:

Metformin HCl – Reduces Glucose Production

Metformin works primarily by reducing glucose production in the liver through inhibition of gluconeogenesis and glycogenolysis. It also enhances insulin sensitivity, allowing the body’s natural insulin to work more efficiently. Additionally, it improves peripheral glucose uptake and utilization by body tissues.

Glimepiride – Stimulates Insulin Release

Glimepiride, a third-generation sulfonylurea, stimulates insulin secretion from pancreatic beta cells in response to blood glucose levels. This targeted stimulation ensures insulin release occurs when needed, helping lower both fasting and post-meal blood sugar levels.

Together, these mechanisms provide better glycemic control compared to monotherapy.

Key Benefits of Amaryl M S.R. Tablets

• Controls fasting and postprandial blood sugar levels
• Enhances insulin sensitivity
• Reduces hepatic glucose production
• Helps stabilize blood sugar fluctuations
• Lowers the risk of diabetes-related complications
• Supports weight management in diabetic patients
• Convenient sustained-release dosing

This combination therapy supports a comprehensive diabetes management plan when used alongside proper diet and exercise.

Who Should Use Amaryl M S.R. 1mg/500mg?

Amaryl M S.R. is prescribed for adults with Type 2 Diabetes who:

• Are inadequately controlled with Metformin alone
• Require additional glycemic control beyond Glimepiride monotherapy
• Need combination therapy under medical supervision
• Are following a structured diabetes treatment program

It is not suitable for Type 1 Diabetes or diabetic ketoacidosis.

Proper Usage & Dosage

Take Amaryl M S.R. Tablets exactly as prescribed by your physician. The tablet should be swallowed whole with a full glass of water, preferably during or after meals. Do not crush or chew the tablet.

Dosage must be individualized based on treatment response and tolerance. The maximum daily dose should not exceed 2000mg of Metformin and 8mg of Glimepiride.

Consistency in dosing schedule and regular blood sugar monitoring are essential for optimal results.

Safety Information & Precautions

Patients should not use this medication if they have:

• Severe kidney or liver disease
• Diabetic ketoacidosis
• Known hypersensitivity to sulfonylureas or biguanides
• G6PD deficiency
• Severe dehydration or respiratory illness
• Recent heart attack or stroke
• Planned surgery or contrast imaging procedures

Hypoglycemia and gastrointestinal discomfort are possible side effects. Lactic acidosis, though rare, is a serious complication associated with Metformin accumulation and requires immediate medical attention.

Alcohol consumption should be avoided due to increased risk of hypoglycemia and lactic acidosis.

Monitoring & Laboratory Tests

Regular monitoring of:

• Fasting and post-meal blood sugar
• HbA1c levels
• Kidney function (serum creatinine, BUN)
• Liver function tests
• Lipid profile
• Electrolytes

These assessments help ensure safe and effective therapy.

Storage Guidelines

Store Amaryl M S.R. Tablets in a cool, dry place at room temperature. Protect from heat, light, and moisture. Keep out of reach of children.

Take Control of Your Diabetes Today

Effective diabetes management requires the right medication, lifestyle commitment, and regular monitoring. Amaryl M S.R. Tablets 1mg/500mg provide a scientifically designed dual-action solution for improved glycemic control.

Consult your healthcare provider today to determine if Amaryl M S.R. is the right step in your diabetes treatment plan and move toward better blood sugar stability and long-term health protection.