Amaryl MSR 2/500MG ( 3 Strips = 30 Tablets )

Comprehensive Blood Sugar Management with Dual Action

Amaryl M SR Tablets 2/500mg provide a clinically established combination of Glimepiride and Metformin HCl in a sustained-release formulation. This dual-action therapy is designed for effective management of Type 2 Diabetes in adults who require better glycemic control than single-drug therapy can provide.

By addressing both insulin resistance and insulin secretion, Amaryl M SR supports stable blood glucose control throughout the day.

How Amaryl M SR Works

The therapeutic effectiveness of Amaryl M SR lies in its complementary mechanisms:

Metformin – Improves Insulin Sensitivity

Metformin reduces glucose production in the liver by inhibiting gluconeogenesis and glycogenolysis. It also slows intestinal glucose absorption after meals and enhances insulin sensitivity. As a result, body cells are better able to absorb and utilize glucose, lowering both fasting and postprandial blood sugar levels.

Glimepiride – Stimulates Insulin Release

Glimepiride, a third-generation sulfonylurea, stimulates pancreatic beta cells to release insulin in response to glucose. By binding to sulfonylurea receptors, it promotes insulin secretion that helps move glucose from the bloodstream into cells for energy production.

Together, these actions provide superior glycemic control compared to monotherapy.

Key Benefits of Amaryl M SR 2/500mg

• Controls fasting and post-meal blood glucose
• Enhances insulin effectiveness
• Supports long-term glycemic stability
• Reduces blood sugar fluctuations
• Helps lower the risk of diabetes-related complications
• Suitable as adjunct therapy when monotherapy is insufficient
• Convenient once-daily sustained-release dosing

This combination therapy is most effective when combined with proper diet, exercise, and regular medical supervision.

Who Should Use This Medication?

Amaryl M SR Tablets 2/500mg are prescribed for:

• Adults diagnosed with Type 2 Diabetes
• Patients inadequately controlled with Metformin or Glimepiride alone
• Individuals requiring combination therapy for improved glycemic outcomes
• Patients following structured diabetes management plans

This medication is not indicated for Type 1 Diabetes or diabetic ketoacidosis.

Recommended Dosage & Administration

The typical starting dose includes:

• Metformin 500mg once daily, which may be gradually increased up to 2000mg daily
• Glimepiride 1–2mg once daily, adjustable up to 8mg daily

The tablet should be taken once daily with the evening meal or as directed by your healthcare provider. Swallow the tablet whole with water. Do not crush or chew.

Dosage must be individualized based on blood glucose levels and patient response.

Important Safety Information

Do not use Amaryl M SR if you have:

• Severe kidney or liver impairment
• Diabetic ketoacidosis
• Hypersensitivity to sulfonylureas or biguanides
• Severe dehydration
• Alcohol dependence

Potential side effects include:

• Hypoglycemia
• Nausea or diarrhea
• Stomach discomfort
• Weight gain

Lactic acidosis is a rare but serious risk associated with Metformin, particularly in patients with renal impairment or hypoxic conditions. Immediate medical attention is required if symptoms such as severe weakness, muscle pain, or difficulty breathing occur.

Alcohol consumption should be avoided to reduce risk of adverse effects.

Monitoring & Laboratory Tests

Regular monitoring is essential for safe therapy:

• Fasting blood glucose
• HbA1c levels
• Kidney and liver function tests
• Vitamin B12 levels during long-term therapy

These tests help ensure safe and effective diabetes management.

Storage Instructions

Store tablets at room temperature in a tightly closed container, away from heat, moisture, and direct sunlight. Dispose of unused medication through a pharmacy for safe handling.

Take Charge of Your Diabetes Management

Achieving stable blood sugar control requires the right combination of medication, lifestyle changes, and regular monitoring. Amaryl M SR Tablets 2/500mg offer a scientifically formulated dual-action solution to help manage Type 2 Diabetes effectively.

Consult your healthcare provider today to determine whether Amaryl M SR is the right addition to your diabetes treatment plan and move toward better glucose control and long-term health protection.